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A previous study has shown that perturbation of this pathway decreases sensitivity to the chemotherapeutic methotrexate and increasing flux through this pathway has been proposed to increase methotrexate efficacy in patients (Kanarek et al., 2018)

10.1111/febs.12401 FEBS J

Although the role of mGluRs has been investigated in macrophage in inflammatory diseases such as multiple sclerosis, the role of mGluRs has not been investigated in macrophage in a cancer model

The most direct consequence is the depletion of antioxidants like glutathione (GSH), antioxidant enzymes including glutathione peroxidase, gamma-glutamylcysteine ligase (-GCL), and SOD1, or related proteins such as nuclear factor erythroid-2-related factor 2 (Nrf2) [26, 61, 68, 90, 91] (Fig

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