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Nevertheless, the immunosuppressive tumor microenvironment (TME) in HCC, characterized by the abundance of inhibitory cytokines (e.g., IL-4, IL-10, and IL-13) can educate the infiltrating macrophages toward an M2 phenotype, thereby attenuating the antitumor immune response and promoting tumor progression [19, 20]

13 C-NMR studies by Scafidi et al

Methods Reagents All chemicals and reagents were purchased from Sigma-Aldrich (St

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These anti-inflammatory and antioxidant effects translate into histological protection (less neuronal loss) and functional improvements in motor behavior

In this process, GSH is constantly oxidized to GSSG by the enzyme glutathione peroxidase.To maintain the intracellular redox balance, GSH is replenished through the reduction GSSG by glutathione reductase enzyme