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Evolution of the cellular stress proteome: From monophyletic origin to ubiquitous function

Kohansal 2009)

Similar content being viewed by others Background Neurofibromatosis type 1 (NF1), first characterised in detail by the German pathologist Friedrich von Recklinghausen in 1882, is an autosomal-dominant genetic disorder that results from biallelic inactivation of the tumour-suppressor gene NF1

These are the genes involved in producing enzymes that allow the body to create and recycle glutathione in the body

However, the chronic inflammatory state that arises in diabetes leads to continuous ROS production, resulting in cellular damage and the depletion of antioxidant systems [9]