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For instance, activating transcription factor 3 (ATF3) binds to the solute carrier family 7 member 11 (SLC7A11) promoter, suppressing SLC7A11 expression, which reduces levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) and hinders the reduction of lipid peroxides

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This phenomenon may be attributed to the pro-oxidative nature of the predominant AhR ligands in these contexts, including oxyindole, IS, TCDD and dioxins

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CHAC1 is often induced under cellular stress, including unfolded protein response signaling, and its activation modulates redox balance and influences apoptosis and ferroptosis 30

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