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On the other hand, decreased mitophagy, together with decreased antioxidant capacity during aging can increased ROS levels in the body

Fatigue/exhaustion yes, it can cause the exact opposite of what it is meant to promote

This suggests that in cultured LEC transcription is not globally impaired by compromising autophagy and that notwithstanding a milder effect on the upregulation of BEC markers, likely due to incomplete shut down of PROX1 expression (Fig

342 Immune senescence, particularly of cytotoxic CD4 + T cells, 343 promotes chronic inflammation and the accumulation of somatic single-nucleotide variants in the CNS