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4.3.1 Ferroptosis and fibrosis induced by kidney stones Kidney stones are a common urinary system disorder, with an incidence rate as high as 14.8% and a recurrence rate of up to 50%

Rather than describing outcomes in terms of symptom relief or treatment, investigators focus on mechanistic language such as changes in specific markers, pathways, or structural features

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74 The intussusceptive microvascular growth (IMG) also called splitting angiogenesis is a novel mode of vessel generation and vascular remodeling that might be acting as an anti-VEGF rescue meditor

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However, complicated mechanisms involved in the pathogenesis of OA significantly limit the development of biological disease-modifying OA drugs (Van Spil et al., 2019)