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herpes) An Internal defibrillator/pacemaker Metal implants (excluding dental) in the treatment area Uncontrolled thyroid gland disorder Varicose veins Pregnant or are undergoing an IVF procedure Skin-related autoimmune diseases Silicone implants and/or injections in the area Yes

The advances in the field of microbiome research envision the future possibility of personalized treatment with probiotics that are specifically adjusted to individual patients

*Correspondence: Raffaela Maione, [email protected] ORCID: Raffaela Maione, orcid.org/0009-0002-0491-2018 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Malabsorption Issues: Conditions like Crohns disease or celiac disease can impair absorption, making injections necessary

Besides the main differential characteristics, other negative findings to rule out common causes of true TMA, such as TTP, HUS, DIC, drug-induced TMA, autoimmune-associated TMA, etc., are also essential to guide primary specific management