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The substantial heterogeneity suggests that future studies should prioritize methodological standardization of stimulation protocols and cognitive assessment criteria to enhance evidence reliability (Figure 7)

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The observed risk modulation associated with BBB permeability followed the hypothesized dose-response relationship, decreasing from low (1.96%) to moderate (1.63%) to high (1.49%) permeability groups (Table 2), with significant differences between the low and high groups

At Second Nature, we combine medication with structured support to build those habits, using the balanced plate model and guidance from registered dietitians