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The candidate agents extend current antibiotics classes with, for example, second-generation polymyxins (MRX-8 and upleganan, both in Phase I), an aminoglycoside (apramycin, Phase I), a tetracycline (zifanocycline, Phase I) and a macrolide (nafithromycin, Phase II) as well as new beta-lactam/beta-lactamase inhibitor (BL/BLI) combinations (ceftibuten/ledaborbactam, Phase I

Neuron 37 , 58395 (2003)

One preclinical study finding BPC-157 inhibited melanoma provides limited reassurance, but comprehensive human oncological safety data would require extensive trials that no one has conducted