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AlphaFold3-predicted 3D structural modeling suggested that KW substitutions alter both the binding affinity and interaction pattern between HMGB1/2 and Importin Alpha 5 (IMA5, a key nuclear import mediator for HMGB1/2) (Figure S5A-B)

Castro, R

It works by inhibiting certain signals in the body that trigger swelling and pain

This one wraps it in liposomes (think of them as protective bubbles made from sunflower lecithin) that carry it straight to your cells

This particular feature has an important role in PD as several drugs have limited ability to cross the BBB on their own (123)

PIKK, phosphatidylinositol-3-kinase-related kinase