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Human studies have only identified minor sex variations in cerebral cortical gene expression

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The end products of purine metabolism, uric acid, a potent antioxidant, have been reported to be found in decreased levels in MDD 71,72,73 , while lower cerebro-spinal fluid (CSF) levels of hypoxanthine and xanthine, the two metabolites preceding uric acid, have previously been linked with depression 74

Further, while we observed that the addition of EDTA improved NAC stability and potency from ~ 33 to ~ 85% under accelerated conditions, ideally less than 10% loss with careful evaluation of degradation products would be necessary to further development