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5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids

This subjective improvement could reflect placebo effect, improved overall nutritional status from paying more attention to diet, natural adaptation to the medication over time, or actual b12 repletion if deficiency existed

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