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doi: 10.1046/j.1365-4362.2000.00943.x [DOI] [PubMed] [Google Scholar] 100.Huh CH, Seo KI, Park JY, Lim JG, Eun HC, Park KC

Abstract Background Peripheral nerve injuries (PNIs) remain one of the great clinical challenges because of their considerable long-term disability potential

Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)