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224,225 In Cu-deficient animals and humans, cardiovascular lesions could be presented as aortic fissures and aortic rupture, possibly due to an altered architecture of elastic fibers

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In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis

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Arch Dermatol