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Although attenuated during the remyelination phase, astrogliosis persisted, particularly in the cortex

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If there is insufficient active B2 (as FAD) or NADPH levels, glutathione is not likely to be recycled sufficiently and may lead to GSSG radical formation

The existing body of literature underscores the challenges associated with GSH's poor bioavailability, attributed to its unfavorable biochemical and pharmacokinetic properties 10,16