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Among oral treatments, methotrexate is the most strongly associated with hepatotoxicity, with long-term use linked to hepatic fibrosis and cirrhosis

Also, CYP is detoxified by glutathione conjugation leading to a reduction in GSH levels and the concomitant rise in oxidized glutathione levels (Abdul-Hamid et al

Furthermore, an overproduction of lipases along with the previously reported enhanced -oxidation (Patil and Jain, 2019) together indicates that the stored lipids are used for energy production (Figure 9)

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Glutamine An amino acid that directly supports the gut by creating balance of the gut microbiome, increases integrity of the intestinal lining, and decreases inflammatory responses from potential inflammatory situations the gut interfaces through stressors

10.1371/journal.pone.0141014 80 LiuX.GaoQ.LiP.ZhaoQ.ZhangJ.LiJ.et al (2013)