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The differential expression patterns of the six signature genes in GSE84437 mirrored those observed in TCGA-STAD (Figure S2A), with significantly elevated expression of DHRS7, CRABP2, CALD1, ALB, and RIMS1 in the high-risk group, whereas NOP2 expression was markedly higher in the low-risk group

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Moreover, it is still not completely clear whether reducing PD-1 expression among exhausted PD-1 high CD8 + T cells enhances sensitivity to anti-PD therapy or whether the expression of checkpoints, such as LAG-3, Tim-3, B and T lymphocyte attenuator (BTLA), and VISTA, can be independent of PD-1

By incorporating antioxidants like glutathione into a wellness plan, we may help mitigate some of the oxidative stress experienced during pregnancy