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It's important to note that these side effects are typically mild and often resolve on their own

Accessed August 16, 2021

Toxicological Sciences, 54(1), 5259

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

He also says this ingredient is safe to use long-term since it's a non-hydroquinone brightening agent

The single published human case series and unpublished clinical trial data provide preliminary safety reassurance but insufficient evidence for clinical efficacy claims