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As the most potent antioxidant produced by the body, glutathione is synthesized from three amino acids: glycine, cysteine, and glutamic acid, primarily within the liver

PMCID: PMC9057907

10.3390/ijms20143433 Int

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Answer and interpretation This is probably valproic acid induced hyperammonia encephalopathy (VHE) VHE has been reported secondary to acute VPA overdose and in chronic normal therapeutic dosing, presenting as an acute and profound decreased level of consciousness, with or without increased seizure activity this is usually in association with an increased serum ammonia level (Mock and Schwetschenau, 2008) Patients at higher risk for VHE include those with liver impairment, on multiple anticonvulsants, or have other causes of increased ammonia production

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