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Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice

in which vitamin D supplementation was given to 11,017 wellness program participants (average dose 6000 IU/day) with the goal of achieving a vitamin D level of at least 40 ng/ml (100 nmol/L)

10.1021/tx00031a016

Compared with other organs in the body, the brain consumes more oxygen, generates more free radicals, has a higher concentration of polyunsaturated fatty acids, and a lower level of antioxidants, and is therefore more susceptible to damage caused by oxidative stress ( Figure 1 Oxidative stress damage may be linked to schizophrenia mechanisms Social isolation, vitamin D deficiency, chronic stress during adolescence, perinatal infections, inflammation, etc.-all of which ultimately lead to oxidative stress ( Figure 2 )

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