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The formation of mercapturic acid pathway and lysine conjugates can be readily considered detoxification reactions since these processes convert very reactive hydrophobic electrophiles into less reactive, water-soluble products 21

Treatment of Protandim protected OLs against oxidative insults and counteracted ROS-induced inhibition of OPC differentiation

Furthermore, ROS can be released in response to a variety of stimuli, such as TNF- and lipopolysaccharide [3646, 169] and they serve as intracellular signals for the activation of redox-sensitive transcription factors [2, 3, 1618, 26, 27, 3646, 164170]

HartmannA.AgurellE.BeeversC.Brendler-SchwaabS.BurlinsonB.2003Recommendations for conducting the in vivo alkaline Comet assay

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Ostergaard L, Stankevicius E, Andersen MR, Eskildsen-Helmond Y, Ledet T, Mulvany MJ, Simonsen U (2007) Diminished NO release in chronic hypoxic human endothelial cells