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Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

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Although MIF shares low sequence homology with natural ligands, such as CXC motif chemokine ligand (CXCL8) and SDF-1 (CXCL12), it contains specific motifs that enable receptor binding upon protein folding

Damage to mitochondrial DNA results in loss of mitochondrial membrane potential, impairment in the electron transport chain, and drives the immune and inflammatory responses (Liu and Chen, 2017), (Figure 3)

These include upregulation of genes linked to the production of ethylene and the synthesis of peptides that bind metals, such as phytochelatins