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However, large ice crystals are formed, if slow freezing is conducted, damaging the bilayer structure [164]

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387,388,389 Oxidation-reduction modifications also participate in the regulation of AMPK activation, where Cys130 and Cys174 of AMPK can form disulfide bonds through oxidation, thereby impeding the binding of AMPK kinase to AMPK and subsequent AMPK activation

Additionally, it was previously shown that the injection of LPS in rat brains was followed by an increase in the inducible nitric oxide synthase (iNOS