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In the last few years, scientists have focused on natural products, especially medicinal plants, to find cost-effective, safer, and potent agents for preventive, prophylactic, and other medicinal purposes

Glioma Tumor cells may acquire resistance to therapies, leading to stress-induced autophagy activation that promotes tumor growth and recurrence [3, 204]

Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]

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