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FOXO4-DRI's selectivity claims are from cell and animal models

GLUT1 is constitutively expressed on the cardiomyocyte plasma membrane and is responsible for basal glucose uptake, whereas GLUT4 is predominantly stored in intracellular vesicles and translocates to the plasma membrane in response to insulin stimulation or increased mechanical workload, thereby enhancing glucose uptake capacity (58)

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Cowman MK, Schmidt TA, Raghavan P, Stecco A

J Inorg Biochem 167:6879

The combined effect of these pathways creates a coordinated signaling response in which cAMP-dependent transcriptional activity and calcium-mediated secretion processes converge