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Multiple keywords were used to search for literature related to gallic acid, liver diseases, liver toxicity, hepatotoxicity, liver injury, alcoholic liver disease, non-alcoholic fatty liver disease, liver cancer, hepatocellular carcinoma, drug-induced liver injury, liver fibrosis, pharmacology, and safety in PubMed, Web of Science, Google Scholar, and Scopus

It has been found that opioids without enhanced internalization, such as morphine, are more likely to cause opioid tolerance, which also suggests that receptor internalization can reduce the occurrence of tolerance

doi: 10.3389/fendo.2024.1325317

Clarification of the interaction of these natural compounds at the cellular and molecular levels is also within the capacity of mechanistic studies

However, additional studies are needed to determine the exact protective mechanism and long-term benefits of curcumin on neuroprotection

After 24 h, nitrite concentrations in the BV-2 cell-free supernatants were measured using the Griess assay