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C.LuV.FarahiJ.et al (2018)

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance

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Before I joined Michigan, I had started working with Rik Pieters on eye tracking research, which offered me the opportunity to delve into the cognitive psychology and neuroscience literatures

For the more curious, here are the details from the literature supporting the headlines above: Because interferon gamma is triggered by viruses and suppresses procalcitonin, therefore, procalcitonin can differentiate bacterial vs viral etiology, therefore, procalcitonin testing can be used to reduce lower respiratory tract infection antibiotic use without affecting mortality A randomized controlled trial, the ProHOSP study, examined outcomes of 1,359 patients in Swiss EDs with acute lower respiratory tract infections (pneumonia, bronchitis, COPD exacerbation) and found procalcitonin-guided antibiotic therapy reduced antibiotic initiation (and duration) without affecting mortality

Liver and kidney function tests can identify any unexpected impacts on organ function