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A phase 2, double-blind, placebo-controlled trial randomized patients with moderate-severe PDPN to subcutaneous fulranumab or placebo

55 Lifestyle factors such as smoking, excessive alcohol consumption, and physical inactivity are linked to DN development, exacerbating oxidative stress and vascular dysfunction

For this reason, gluten is often stigmatized as responsible for alterations in human well-being and health [140]

UA administration downregulated inflammatory cytokines/chemokine and immune cells in mice with cisplatin-induced nephrotoxicity [37] and resulted in reduced levels of the endoplasmic reticulum stress (ERS) markers, phosphorylated mitogen-activated protein kinase 8 and pro-inflammatory interleukins in obese mice [27]

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