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Most current therapeutic candidates for NDDs face challenges in crossing the bloodbrain barrier, substantially limiting their clinical efficacy (Ross and Poirier, 2004)

Sleep quality may also improve because recovery processes stabilize

Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism

10.1038/jhg.2014.41 J

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Odakowska M., ciskalska M., Kepinska M., Marek G., Milnerowicz H

Cancer Res 56(13):3010-20, 1996