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therefore, there are many resistant and refractory patients

Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells Mol Cell Biol 2000 20 : 53815391 Visconti R, Cerutti J, Battista S, Fedele M, Trapasso F, Zeki K, Miano MP, de Nigris F, Casalino L, Curcio F, Santoro M, Fusco A

Materials and Methods Drugs and chemicals All chemicals used were of the highest available purity and were obtained from Roth (Karlsruhe, Germany), Sigma-Aldrich (Steinheim, Germany), or Merck (Darmstadt, Germany)

Important: NAD+ dosing is individualized and will vary depending on patient needs

10.1016/j.arr.2018.11.003 248 ZhuY.TchkoniaT.Fuhrmann-StroissniggH.DaiH

(1) sUA activates innate immunity