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ArticlePubMed 47

More than 90% of PDAC cases harbor mutations in KRAS and mutant KRAS signaling is linked to increased ROS production and, therefore, increased dependency on cystine import via SLC7A11

Thus, for ferroptosis to proceed, PUFAs were required to intersect into membrane to serve as the targets for peroxidation and iron-catalyzed free radical production

However, in this study, we performed a comparative trial and the use of compensation values was not necessary

Personalized medicine approaches are being explored to address these genetic variations and optimize treatment strategies

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