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The consistency of the genetic instrument effects was assessed using the IVW method and MR-Egger regression

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[7] So the honest one-line summary is that both build on GLP-1 but recruit a different second pathway amylin for CagriSema, GIP for tirzepatide and there is a further structural difference underneath that: CagriSema achieves its dual action with two separate peptides, while tirzepatide achieves its dual action with one

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