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People with low energy, fatigue, vegetarians or vegans, those with absorption issues (e.g., from gastric surgery or digestive conditions), or anyone diagnosed with B12 deficiency can benefit

Ive found that most older patients prefer oral supplements over regular vitamin B12 injections, which is understandable

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These include: One can also take the following Vitamin B12 deficiency self-care actions to help avoid a vit b 12 deficiency: The risk of several health issues may increase with prolonged B12 deficiency

For context on SAMe and related evidence limits, see the NIH NCCIH resource S-Adenosyl-L-Methionine (SAMe): In Depth