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The intervention group received a single injection of 1 mL/kg of 75% hypertonic glucose directly into the facet joints (L1-L2, L5-S1) [64]

The risk-based approach for evaluating newly obtained HBM data is challenging and requires information on relationships between biomarker concentrations and mycotoxin intake from human and/or animal studies or toxicokinetic modelling, as well as toxicity profiles including mode of action

[43] We believe that the updated descriptor accurately reflects the devices intended to be described by C1739, inclusive of the SCOUT MD TM Delivery System, and addresses the applicant's concerns that the prior descriptor was overly broad

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All mice were sacrificed by cervical decapitation under deep isoflurane anesthesia