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Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses

Genetic CH animal models have relatively stable phenotypes without surgical trauma and are technically easy to handle and maintain 11

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Surgical and facility costs for outpatient implantation procedures add approximately $10,000

Identification of a genetic risk factor for metformin-induced vitamin B 12 deficiency

Nutritional Considerations: Because orlistat decreases fat absorption, it can also reduce the absorption of fat-soluble vitamins (A, D, E, and K)