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and cabozantinib for advanced RCC (clinicaltrials.gov ID: NCT03428217) 46

Deficiency of 1 -antitrypsin presents in infancy as liver disease, or in adulthood as lung disease 1 -Antitrypsin is a member of the serpin family of serine protease inhibitors, and, contrary to its name, its predominant target is macrophage-derived elastase

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al

Am J Chin Med 26, 199209 (1998)

These signalling pathway intermediates are found in diverse cellular regulatory signalling axis, including cell proliferation, survival, cell cycle, cytoskeletal functions, and transcription