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APS have been extensively investigated as an immunostimulant and anti-aging, anti-diabetic, anti-tumor, and antiviral agent (Zheng et al., 2020)

Impaired catabolism of branched-chain amino acidsmodulated by pathogenic variants in BCKDHA and loss-of-function alleles in PPM1Kcompromises tissue-selective disposal of these metabolites, thereby fostering insulin resistance and accelerating the progression of type 2 diabetes mellitus (30)

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Reduced GPX4 (glutathione peroxidase 4) activity and GSH levels were also observed (219)

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