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Acknowledgements The study was funded by InBrain Pharma, France, a spin-off of the research academic team UMR-S 1172 (University of Lille, INSERM, University Hospital of Lille), which delegated the promotion of the study to the University Hospital of Lille, France

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This pathway gene list formed the basis of the hypoxia- associated network constructed based on published pathway graphs (Supplementary Table 3 and Supplementary Figs

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