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From this perspective, it is interesting to note that we recently reported that transferrin plays an important role in both high dietary iron-induced liver fibrosis and carbon tetrachloride (CCl 4 )-induced liver fibrosis in mice, and inhibiting ferroptosis potently prevented these effects

& Yin, L

"The identity of glutathione S -transferase B with ligandin, a major binding protein of liver"

The acetyl group provides a plausible protective mechanism

Key Points One-carbon metabolism integrates cellular nutrient status by cycling carbon units from amino acid inputs to generate diverse outputs, including redox maintenance and cellular biosynthesis