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fixed modification was carbamidomethylation on cysteine

Mar 2010;6(1):74-5

No pharmacokinetic data exists for severe renal impairment below a creatinine clearance of 20 mL/min, and clinical caution is warranted in this subgroup

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it is elevated in acetaminophen overdose patients and can be detected in humans with moderate liver injury 29,31

Water Retention: Temporary fluid buildup that diminishes with dosage adjustment