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Putrescine promoted pigmentation in human skin explants and primary normal human epidermal melanocytes by inducing TYR, the rate-limiting enzyme in melanin synthesis [208]

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For example, KMO deficiency in male mice elevates KYNA and induces depressive-like behaviours via 7nAChR antagonism, impairing cholinergic modulation of prefrontal circuits, effects that are reversed by restoring 7nAChR signalling [71]

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