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In contrast to their expectations, the results have shown that daily supplementation with vitamin C and vitamin A for 4 weeks not only failed to improve the insulin responsiveness but also decreased the expression of ROS-sensitive transcriptional regulators, molecular mediators of ROS defense (SOD 1 and 2, glutathione peroxidase) [90]

In a mouse model of AD, probiotic treatment with Lactobacillus and Bifidobacterium strains improved cognitive function and reduced amyloid-beta deposition, supporting a neuroprotective role of gut microbiota modulation (Bonfili et al., 2020)

2 However, it is not a treatment strategy for cognitive decline, cognitive impairment, or dementia

doi: 10.1016/j.neuropharm.2015.11.005 153 SadekB.SaadA.LataczG.KuderK.OlejarzA.KarczT.et al

Leung SSY, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, et al

Chronic-plus-binge alcohol leads to hepatocyte necrosis in the liver, causing proinflammatory response