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6 Conclusion Ferroptosis, a regulated form of cell death driven by iron accumulation and lipid peroxidation, has been increasingly recognized as a critical contributor to the pathogenesis and progression of Alzheimers disease (AD)

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Initial screening of the in vivo activity of the LiTE and Albu-LiTE-HB was investigated in an immunodeficient C57BL/6 RAG1 knockout mouse model inoculated with a 2:1 mixture of HT-29 cells and human PBMCs using multiple (8) drug doses to compensate for the short half-life of the unfused LiTE (Supplementary Fig

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Alerts for potential bacterial mutagenicity of the impurity may be overruled by a negative OECD TG471-compliant Ames test (International Council for Harmonisation 2023)