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By converting NAD + to ADP-ribose and nicotinamide, CD38 governs organismal NAD + homeostasis and the activity of NAD + -dependent cellular enzymes

Also, patients should be warned about the danger of taking folic acid in place of Vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration

4,5,6 The term pernicious anaemia refers to an autoimmune disease that destroys the parietal cells, leading to a lack of IF and thus B12 deficiency

SIRT1 is part of a family of proteins called sirtuins, known as longevity genes. It uses NAD+ as a fuel source to repair DNA, reduce inflammation, and improve stress resistance