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Other important factors for HSC activation are platelet-derived growth factor (PDGF) released from platelets, and endothelin-1 from endothelial cells

Our cumulative knowledge of these processes is advancing efforts to identify and target pathways of neurotoxicity driven by atypical SOD1 in multiple incurable neurodegenerative conditions

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Neurosci Bull 22:288293 Ferrari CC, Tarelli R (2011) Parkinson's disease and systemic inflammation