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In turn, when applied following a combination of RFA and TACE, CIK therapy has been revealed in meta-analysis data to be associated with higher 1-year RFS and 1- and 2-year OS than RFA plus TACE alone (116), and retrospective analyses of HCC patients treated with this triple therapy (n = 85 and n = 58, respectively) demonstrated significantly longer OS and PFS (117) as well as elevated peripheral Tregs and NK cells, lower CD8+ T cell levels, and higher general functioning scores than those who did not receive immunotherapy (118)

Certain diseases and pharmacological treatments may contribute to iron overload in patients

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101,102 ME2 depletion, accompanied by an increased NADP + /NADPH ratio and ROS levels, impacts PI3K/AKT signaling and enhances the sensitivity of erythroleukemia and NSCLC cells to cisplatin

V.BassanM.DeSilvaT.TanakaK.et al (2004)

Cell 24 , 23982405 (2013)