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Its the result of interacting biological systemsenergy metabolism, oxidative stress, immune signaling, and structural integritychanging over time

Critical Reviews in Food Science and Nutrition, 64 (10), 31513166

Low concentrations of NO may prevent apoptosis, however pathologically high concentrations of NO, as well as increased superoxide generation by NO synthase due to lack of arginine, may promote cell death by peroxynitrite generation [21]

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