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Description

Gut Microbes (2015) 6:3347

10.1007/s00441-013-1584-z 99

M.BoultonS

Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T

Equally important is the development of biomarkers reflecting iron-handling capacity, lipid oxidative signatures, or ferroptosis-associated cytokine patterns to guide patient stratification and optimize therapy