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They demonstrated that T cell-derived IFN- activates the JAK/STAT1 pathway, resulting in the formation of STAT1 homodimers that inhibit SLC7A11 transcription ( + T cells, the tumor immune microenvironment (TIME) considerably affects this mechanism, possibly restricting ferroptosis in immunologically inert malignancies ( 4 Ferroptosis and cell death in tumor immunology Ferroptosis represents a unique form of regulated cell death characterized by excessive accumulation of lipid peroxides and reactive oxygen species (ROS)

Reich N, Hlscher C

Figure: Accessed 5 July 23

Jun 2005;24(2):121-4

Core transcriptional regulatory circuitry in human embryonic stem cells

which all contribute to our load of oxidative stress load