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doi: 10.1016/j.rpth.2024.102349

A study of 726 people with insulin-dependent diabetes without retinopathy reported that tight blood sugar (glucose) control over an average 6.5-year follow-up was associated with a 76% reduced risk of developing diabetic retinopathy

Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

Topical ambroxol cream (20%) was used for the treatment of severe neuropathic pain in seven patients unresponsive to standard therapies, e.g., lidocaine or capsaicin patches, in the retrospective study [124], providing individual pain reductions within a period lasting for several hours

Parallel studies indicate that physiologic dopamine signaling generally inhibits NLRP3 activity via receptor-mediated pathways, implying that the gradual loss of dopamine in PD removes an endogenous anti-inflammatory brake, exacerbating neuroinflammation

Soil selenium (Se)biofortification changes the physiological, biochemical and epigenetic responses to water stress in Zea mays L